Overcoming the immunosuppressive tumor microenvironment is a promising strategy in anticancer therapy. L-kynurenine, a strong immunosuppressive metabolite can be degraded through kynureninases.

Tailor-made enzymes empower a wide range of versatile applications, although searching for the desirable enzymes often requires high throughput screening and thus poses significant challenges. In this study, we employed homology searches and protein language models to discover and prioritize enzymes by their kinetic parameters.

The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown.

Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory mucosal disease of unknown etiology. The lack of suitable animal models has hampered understanding its etiopathogenesis.

SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating the lysosomal degradation of CES1 (carboxylesterase 1), crucial for triglyceride (TG) breakdown in the liver.

Professor Choi’s research team at SNU has identified the Vibrio vulnificus transcription factors at a genome-wide scale and characterized their functions comprehensively, proposing novel targets to control the pathogen.

Professor Sunghee Baek's team at SNU identified PHF16 as key to intestinal homeostasis after injury. PHF16 restores the epithelium by activating RAR/RXR target genes via HBO1 histone acetylation and suppressing YAP/TAZ via CDC73 ubiquitination. Its role offers insights for gut repair therapies.

Emission lines from complex organic molecules in B335 were observed in four epochs, spanning a luminosity burst of about 10 years duration. The emission lines increased dramatically in intensity as the luminosity increased, but they have decreased only slightly as the luminosity has decreased.

Despite a dramatic increase in ischemic stroke incidence worldwide, effective therapies for attenuating sequelae of cerebral infarction are lacking. This study investigates the use of human mesenchymal stem cells (hMSCs) induced toward glia-like cells (ghMSCs) to ameliorate chronic sequelae resulting from cerebral infarction.

HEPN-MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity.

Professor Ki Hoon Lee's research team from the Department of Agriculture, Forestry, and Bioresources at SNU developed a biomimetic spinning process by leveraging silk fibroin's liquid-liquid phase separation, followed by acidification and shear force to produce fibers.

Prof. Doil Choi and research team identified multiple resistance genes against various Phytophthora pathogens that threat wide-range of important crop species